Mib2
Developmental stage
Highly expressed in neonate and adult, but only slightly in embryos. In 10.5 dpc embryos, it is weakly expressed in the tail bud and limb buds. Expressed in the same pattern than MIB1 in the skin and intestine at postnatal day 1 (P1) and in the hair follicle in the skin in the adult.
Function
E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors.
Pathway
Protein modification; protein ubiquitination.
Post-translational modifications
Ubiquitinated. Possibly via autoubiquitination.
Tissue Specificity
Highly expressed in brain, heart, liver and kidney.
Cellular localization
- Cytoplasm
- Endosome
- Colocalizes with endosomal compartments.
Alternative names
Skd, Mib2, E3 ubiquitin-protein ligase MIB2, Dystrophin-like protein, Mind bomb homolog 2, RING-type E3 ubiquitin transferase MIB2, Skeletrophin, Dyslike, Mind bomb-2