MICU2

EF-hand domains 1 and 4 have high affinity for calcium and act as sensors of mitochondrial matrix calcium levels (PubMed:24503055, PubMed:31397067). EF-hand domains 2 and 3 are degenerate (PubMed:31397067).

Calcium sensor of the mitochondrial calcium uniporter (MCU) channel, which senses calcium level via its EF-hand domains (PubMed:24503055, PubMed:24560927, PubMed:26903221, PubMed:28615291, PubMed:30699349, PubMed:31397067, PubMed:32494073, PubMed:32667285, PubMed:32762847, PubMed:32790952). MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium (PubMed:24560927, PubMed:26903221, PubMed:28615291, PubMed:30699349, PubMed:31397067, PubMed:32148862, PubMed:32494073, PubMed:32667285, PubMed:32762847, PubMed:32790952). At low calcium levels, MICU1 occludes the pore of the MCU channel, preventing mitochondrial calcium uptake (PubMed:32494073, PubMed:32667285, PubMed:32762847). At higher calcium levels, calcium-binding to MICU1 and MICU2 induces a conformational change that weakens MCU-MICU1 interactions and moves the MICU1-MICU2 heterodimer away from the pore, allowing calcium permeation through the MCU channel (PubMed:32494073, PubMed:32667285, PubMed:32762847).

Belongs to the MICU1 family. MICU2 subfamily.

• Mitochondrion intermembrane space
• Mitochondrion inner membrane
• Recruited to the mitochondrial inner membrane via its association with the uniplex complex.

EFHA1, MICU2, hMICU3, EF-hand domain-containing family member A1

• entrezGene:221154
• omim:610632
• swissprot:Q8IYU8

Proteins

Immunology & Infectious Disease

49666Da