MIDN
Domain
Contains three domains that function in concert to promote proteasomal degradation of bound substrates. Contains a ubiquitin-like domain (Ubl) toward its N-terminus that is necessary to promote substrate degradation. In the middle, two domains termed Catch1 and Catch2 are necessary and sufficient to interact with unstructured regions within substrates. The long C-terminal region associates with the proteasome.
Function
Facilitates the ubiquitin-independent proteasomal degradation of stimulus-induced transcription factors such as FOSB, EGR1, NR4A1, and IRF4 to the proteasome for degradation (PubMed:37616343). Promotes also the degradation of other substrates such as CBX4 (By similarity). Plays a role in inhibiting the activity of glucokinase GCK and both glucose-induced and basal insulin secretion.
Cellular localization
- Nucleus
- Nucleolus
- Nucleus
- Cytoplasm
- Cytosol
- Detected in the nucleus and nucleolus with no expression in the cytoplasm (By similarity). However, a later study finds expression in the nucleus and cytoplasm with no expression in the nucleolus (PubMed:24187134).
Alternative names
Midnolin, Midbrain nucleolar protein, MIDN