Milr1
Function
Immunoglobulin-like receptor which plays an inhibitory role in degranulation of mast cells. Negatively regulates IgE-mediated mast cell activation and suppresses the type I immediate hypersensitivity reaction.
Post-translational modifications
N-glycosylated.
Tissue Specificity
Expressed in myeloid cells (dendritic cells, macrophages and neutrophils but not in T-cells, B-cells or natural killer cells) and mast cells (at protein level).
Cellular localization
- Cell membrane
- Single-pass type I membrane protein
- Isoform 2
- Secreted
Alternative names
Gm885, Mca32, Milr1, Allergin-1, Allergy inhibitory receptor 1, Mast cell antigen 32, Mast cell immunoglobulin-like receptor 1, MCA-32, Mast cell Ag-32