Allergin 1

Immunoglobulin-like receptor which plays an inhibitory role in degranulation of mast cells. Negatively regulates IgE-mediated mast cell activation and suppresses the type I immediate hypersensitivity reaction (By similarity).

N-glycosylated.

Expressed in myeloid cells (dendritic cells, macrophages and neutrophils, weak expression on B-cells but not in T-cells or natural killer cells), peripheral blood basophils and mast cells (at protein level).

• Cell membrane
• Single-pass type I membrane protein

C17orf60, MCA32, MILR1, Allergin-1, Allergy inhibitory receptor 1, Mast cell antigen 32, Mast cell immunoglobulin-like receptor 1, MCA-32

• entrezGene:284021
• swissprot:Q7Z6M3

Proteins

Immunology & Infectious Disease

38735Da