Mitochondrial peptide methionine sulfoxide reductase
Function
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
Sequence Similarities
Belongs to the MsrA Met sulfoxide reductase family.
Tissue Specificity
Ubiquitous. Highest expression in adult kidney and cerebellum, followed by liver, heart ventricles, bone marrow and hippocampus.
Cellular localization
- Isoform 1
- Mitochondrion
- Isoform 2
- Cytoplasm
- Isoform 3
- Cytoplasm
- Nucleus
- Isoform 5
- Cytoplasm
- Membrane
- Lipid-anchor
Alternative names
Mitochondrial peptide methionine sulfoxide reductase, Peptide-methionine (S)-S-oxide reductase, Protein-methionine-S-oxide reductase, Peptide Met(O) reductase, PMSR, MSRA