MKNK1
Function
May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap.
Post-translational modifications
Dual phosphorylation of Thr-250 and Thr-255 activates the kinase. Phosphorylation of Thr-385 activates the kinase. MAPK3/ERK1 is one of the kinases which activate MKNK1/MNK1. Phosphorylation by PAK2 leads to a reduced phosphorylation of EIF4G1.
Sequence Similarities
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
Tissue Specificity
Ubiquitous.
Cellular localization
- Isoform 2
- Cytoplasm
- Isoform 3
- Cytoplasm
- Nucleus
Alternative names
MNK1, MKNK1, MAP kinase-interacting serine/threonine-protein kinase 1, MAP kinase signal-integrating kinase 1, MAPK signal-integrating kinase 1, Mnk1