MLANA

Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes.

Acylated.

Expression is restricted to melanoma and melanocyte cell lines and retina.

• Endoplasmic reticulum membrane
• Single-pass type III membrane protein
• Golgi apparatus
• Golgi apparatus
• trans-Golgi network membrane
• Melanosome
• Also found in small vesicles and tubules dispersed over the entire cytoplasm. A small fraction of the protein is inserted into the membrane in an inverted orientation. Inversion of membrane topology results in the relocalization of the protein from a predominant Golgi/post-Golgi area to the endoplasmic reticulum. Melanoma cells expressing the protein with an inverted membrane topology are more effectively recognized by specific cytolytic T-lymphocytes than those expressing the protein in its native membrane orientation.

MART1, MLANA, Melanoma antigen recognized by T-cells 1, MART-1, Antigen LB39-AA, Antigen SK29-AA, Protein Melan-A

• entrezGene:2315
• omim:605513
• swissprot:Q16655

Proteins

Immunology & Infectious Disease

• Immuno-oncology

13157Da