MLF1
Function
Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.
Involvement in disease
A chromosomal aberration involving MLF1 is a cause of myelodysplastic syndrome (MDS). Translocation t(3;5)(q25.1;q34) with NPM1/NPM.
Post-translational modifications
Phosphorylation is required for binding to YWHAZ.
Sequence Similarities
Belongs to the MLF family.
Tissue Specificity
Most abundant in testis, ovary, skeletal muscle, heart, kidney and colon. Low expression in spleen, thymus and peripheral blood leukocytes.
Cellular localization
- Cytoplasm
- Nucleus
- Cell projection
- Cilium
- Cytoplasm
- Cytoskeleton
- Cilium basal body
- Shuttles between the cytoplasm and nucleus.
Alternative names
Myeloid leukemia factor 1, Myelodysplasia-myeloid leukemia factor 1, MLF1