MLX
Function
Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MAD1, MAD4, MNT, WBSCR14 and MLXIP which recognizes the core sequence 5'-CACGTG-3'. The TCFL4-MAD1, TCFL4-MAD4, TCFL4-WBSCR14 complexes are transcriptional repressors. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation.
Tissue Specificity
Expressed in all tissues tested, including spleen, thymus, prostate, ovary, intestine, colon, peripheral blood leukocyte, heart, liver, skeletal muscle and kidney. Lower levels of expression in testis, brain, placenta and lung.
Cellular localization
- Isoform Alpha
- Cytoplasm
- Found predominantly in the cytoplasm (PubMed:10918583).
- Isoform Beta
- Cytoplasm
- Found predominantly in the cytoplasm (PubMed:10918583).
- Isoform Gamma
- Nucleus
- Found predominantly in the nucleus (PubMed:10918583).
Alternative names
BHLHD13, TCFL4, MLX, Max-like protein X, Class D basic helix-loop-helix protein 13, Max-like bHLHZip protein, Protein BigMax, Transcription factor-like protein 4, bHLHd13