MMEL1
Function
Metalloprotease involved in sperm function, possibly by modulating the processes of fertilization and early embryonic development. Degrades a broad variety of small peptides with a preference for peptides shorter than 3 kDa containing neutral bulky aliphatic or aromatic amino acid residues. Shares the same substrate specificity with MME and cleaves peptides at the same amide bond (By similarity).
Post-translational modifications
N-glycosylated.
Sequence Similarities
Belongs to the peptidase M13 family.
Tissue Specificity
Predominantly expressed in testis. Weakly expressed in brain, kidney and heart.
Cellular localization
- Membrane
- Single-pass type II membrane protein
- Secreted
- A secreted form produced by proteolytic cleavage also exists.
Alternative names
MELL1, MMEL2, NEP2, MMEL1, Membrane metallo-endopeptidase-like 1, Membrane metallo-endopeptidase-like 2, NEP2(m), Neprilysin II, Neprilysin-2, NEPII, NL2