Mmp10
Domain
The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Function
Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activates procollagenase.
Sequence Similarities
Belongs to the peptidase M10A family.
Tissue Specificity
Expressed in small intestine. Weak levels in heart and lung.
Cellular localization
- Secreted
- Extracellular space
- Extracellular matrix
Alternative names
Stromelysin-2, SL-2, Matrix metalloproteinase-10, Transin-2, MMP-10, Mmp10