MMP11
Domain
The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Function
May play an important role in the progression of epithelial malignancies.
Post-translational modifications
The precursor is cleaved by a furin endopeptidase.
Sequence Similarities
Belongs to the peptidase M10A family.
Tissue Specificity
Specifically expressed in stromal cells of breast carcinomas.
Cellular localization
- Secreted
- Extracellular space
- Extracellular matrix
Alternative names
STMY3, MMP11, Stromelysin-3, SL-3, ST3, Matrix metalloproteinase-11, MMP-11