The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.
Belongs to the peptidase M10A family.
Found in alveolar macrophages but not in peripheral blood monocytes.
Proteins
Immuno-oncology
54002Da
We found 14 products in 4 categories
ab314017
ab137443
ab137444
ab213811
ab131994