MMP12

The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.

May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3 (By similarity).

Belongs to the peptidase M10A family.

• Secreted
• Extracellular space
• Extracellular matrix

Mmel, Mmp12, Macrophage metalloelastase, MME, Matrix metalloproteinase-12, MMP-12

• entrezGene:117033
• swissprot:Q63341

Proteins

Immuno-oncology

53738Da