MMP16
Developmental stage
Expressed in tissues undergoing reconstruction. Present in fetal tissues, especially in brain. Expression seems to decline with advanced development.
Domain
The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Function
Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells.
Post-translational modifications
The precursor is cleaved by a furin endopeptidase.
Sequence Similarities
Belongs to the peptidase M10A family.
Tissue Specificity
Expressed in heart, brain, placenta, ovary and small intestine. Isoform Short is found in the ovary.
Cellular localization
- Isoform Long
- Cell membrane
- Single-pass type I membrane protein
- Extracellular side
- Localized at the cell surface of melanoma cells.
- Isoform Short
- Secreted
- Extracellular space
- Extracellular matrix
- Cell surface
- Localized at the cell surface of melanoma cells.
Alternative names
C8orf57, MMPX2, MMP16, Matrix metalloproteinase-16, MMP-16, MMP-X2, Membrane-type matrix metalloproteinase 3, Membrane-type-3 matrix metalloproteinase, MT-MMP 3, MTMMP3, MT3-MMP, MT3MMP