Expression initiates prior to the onset of dentin mineralization and continues throughout the secretory stage of amelogenesis.
The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation. Cleaves aggrecan at the '360-Asn-|-Phe-361' site.
Amelogenesis imperfecta, hypomaturation type, 2A2
AI2A2
A defect of enamel formation. The disorder involves both primary and secondary dentitions. The teeth have a shiny agar jelly appearance and the enamel is softer than normal. Brown pigment is present in middle layers of enamel.
None
The disease is caused by variants affecting the gene represented in this entry.
Autoactivates at least at the 107-Asn-|-Tyr-108 site.
Belongs to the peptidase M10A family.
Expressed specifically in the enamel organ.
Matrix metalloproteinase-20, MMP-20, Enamel metalloproteinase, Enamelysin, MMP20
Proteins
Immunology & Infectious Disease
54387Da
We found 3 products in 1 category
ab198815