MMP23B

Domain

The ShKT domain associates with, and blocks several potassium channels in the nanomolar to low micromolar range. The relative affinity is Kv1.6 > Kv1.3 > Kv1.1 = Kv3.2 > Kv1.4 (By similarity).

Function

Protease. May regulate the surface expression of some potassium channels by retaining them in the endoplasmic reticulum (By similarity).

Post-translational modifications

N-glycosylated.

Proteolytic cleavage might yield an active form.

Sequence Similarities

Belongs to the peptidase M10A family.

Tissue Specificity

Predominantly expressed in ovary, testis and prostate.

Cellular localization

• Endoplasmic reticulum membrane
• Single-pass type II membrane protein
• Membrane
• Single-pass type II membrane protein
• A secreted form produced by proteolytic cleavage may also exist.

Alternative names

MMP21, MMP22, MMP23B, Matrix metalloproteinase-23, MMP-23, Femalysin, MIFR-1, Matrix metalloproteinase-21, Matrix metalloproteinase-22, MMP-21, MMP-22

Database links

swissprot:O75900 omim:603321 omim:603320 entrezGene:8510 entrezGene:8511