MMP24
Domain
The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
The PDZ-binding motif (also named EWV motif) is required for interaction with PDZ domains of APBA3 and recycling through the trans-Golgi network.
Function
Metalloprotease that mediates cleavage of N-cadherin (CDH2) and acts as a regulator of neuro-immune interactions and neural stem cell quiescence. Involved in cell-cell interactions between nociceptive neurites and mast cells, possibly by mediating cleavage of CDH2, thereby acting as a mediator of peripheral thermal nociception and inflammatory hyperalgesia. Key regulator of neural stem cells quiescence by mediating cleavage of CDH2, affecting CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate their quiescence. May play a role in axonal growth. Able to activate progelatinase A. May also be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans. Cleaves partially fibronectin, but not collagen type I, nor laminin (By similarity).
Post-translational modifications
Cleaved by a furin endopeptidase in the trans-Golgi network.
Sequence Similarities
Belongs to the peptidase M10A family.
Tissue Specificity
Predominantly expressed in brain, kidney, pancreas and lung. Overexpressed in a series of brain tumors, including astrocytomas and glioblastomas.
Cellular localization
- Matrix metalloproteinase-24
- Cell membrane
- Single-pass type I membrane protein
- Golgi apparatus
- trans-Golgi network membrane
- Single-pass type I membrane protein
- Recycled back to the plasma membrane through the trans-Golgi network via interaction with APBA3.
- Processed matrix metalloproteinase-24
- Secreted
- Extracellular space
- Extracellular matrix
- Also shed from cell surface as soluble proteinase, by a proteolytic cleavage.
Alternative names
MT5MMP, MMP24, Matrix metalloproteinase-24, MMP-24, Membrane-type matrix metalloproteinase 5, Membrane-type-5 matrix metalloproteinase, MT-MMP 5, MTMMP5, MT5-MMP