MMP26

Domain

The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.

Function

May hydrolyze collagen type IV, fibronectin, fibrinogen, beta-casein, type I gelatin and alpha-1 proteinase inhibitor. Is also able to activate progelatinase B.

Sequence Similarities

Belongs to the peptidase M10A family.

Tissue Specificity

Expressed specifically in uterus and placenta. Is also widely expressed in malignant tumors from different sources as well as in diverse tumor cell lines.

Cellular localization

• Secreted
• Extracellular space
• Extracellular matrix

Alternative names

Matrix metalloproteinase-26, MMP-26, Endometase, Matrilysin-2, MMP26

Database links

swissprot:Q9NRE1 omim:605470 swissprot:Q3MJ78 entrezGene:56547