MMP28
Domain
The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Function
Can degrade casein. Could play a role in tissues homeostasis and repair.
Post-translational modifications
The precursor is cleaved by a furin endopeptidase.
Sequence Similarities
Belongs to the peptidase M10A family.
Tissue Specificity
Expressed at high levels in testes and lung. Low levels are detected in kidney, pancreas and skin. Also expressed in fetal lung, brain, skeletal muscle and kidney. Expressed selectively in keratinocytes. Widely expressed in several carcinomas as well. Is up-regulated in response to injury in the skin.
Cellular localization
- Secreted
- Extracellular space
- Extracellular matrix
Alternative names
MMP25, UNQ1893/PRO4339, MMP28, Matrix metalloproteinase-28, MMP-28, Epilysin