MMP3

Domain

The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.

Function

Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase.

Sequence similarities

Belongs to the peptidase M10A family.

Cellular localization

• Secreted
• Extracellular space
• Extracellular matrix
• Secreted

Alternative names

• Stromelysin-1
• SL-1
• Matrix metalloproteinase-3
• PTR1 protein
• Transin-1
• MMP-3
• Mmp3

Database links

• entrezGene:171045
• swissprot:P03957

Target type

Proteins

Primary research area

Oncology

Other research areas

• Neuroscience

Molecular weight

53428Da