MMP7

The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.

Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase.

Belongs to the peptidase M10A family.

• Secreted
• Extracellular space
• Extracellular matrix

MPSL1, PUMP1, MMP7, Matrilysin, Matrin, Matrix metalloproteinase-7, Pump-1 protease, Uterine metalloproteinase, MMP-7

• entrezGene:4316
• omim:178990
• swissprot:P09237

Proteins

Immunology & Infectious Disease

29677Da