Mmp7
Domain
The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Function
Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase (By similarity).
May play a role in tissue reorganization.
Sequence Similarities
Belongs to the peptidase M10A family.
Tissue Specificity
Expressed in the intestinal epithelium (at protein level).
Cellular localization
- Secreted
- Extracellular space
- Extracellular matrix
Alternative names
Matrilysin, Matrin, Matrix metalloproteinase-7, Pump-1 protease, Uterine metalloproteinase, MMP-7, Mmp7