The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase (By similarity).
May play a role in tissue reorganization.
Belongs to the peptidase M10A family.
Expressed in the intestinal epithelium (at protein level).
Matrilysin, Matrin, Matrix metalloproteinase-7, Pump-1 protease, Uterine metalloproteinase, MMP-7, Mmp7
Proteins
Immunology & Infectious Disease
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