Mmp8
Domain
The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Function
Can degrade fibrillar type I, II, and III collagens.
Sequence Similarities
Belongs to the peptidase M10A family.
Cellular localization
- Cytoplasmic granule
- Secreted
- Extracellular space
- Extracellular matrix
- Stored in intracellular granules.
Alternative names
Neutrophil collagenase, Matrix metalloproteinase-8, MMP-8, Mmp8