MMP8
GeneName
MMP8
Summary
MMP8, also known as MMP-8 or neutrophil collagenase, is a 53 kDa member of the matrix metalloproteinase family. It is primarily expressed in neutrophils and is secreted into the extracellular matrix and extracellular space. MMP8 plays a crucial role in the degradation of collagen and other extracellular matrix components, facilitating processes such as extracellular matrix disassembly and organisation. Additionally, it is involved in various biological processes including the cellular response to lipopolysaccharide and the regulation of neuroinflammatory responses through its endopeptidase and metalloendopeptidase activities, as well as its ability to bind zinc ions and tumour necrosis factor.
Importance
MMP8 is relevant to: - Inflammatory responses and tissue remodelling due to its role in collagen degradation and extracellular matrix turnover - Neuroinflammation, as it positively regulates microglial cell activation and tumour necrosis factor production - Pathological conditions such as cancer, where it may influence tumour progression through extracellular matrix dynamics - Diseases associated with collagen degradation, including arthritis and chronic wounds, highlighting its potential as a therapeutic target.
Top Products
For researchers investigating MMP8, we highly recommend the top-selling recombinant antibody, Anti-MMP8 antibody [EP1252Y] (ab81286). This well-cited product has garnered 46 citations, reflecting its reliability and trust within the scientific community. It has been validated for use in several applications, including Western blotting (WB), immunohistochemistry (IHC), and immunoprecipitation (IP), making it a versatile choice for various experimental needs. The recombinant nature of this antibody ensures batch-to-batch consistency, providing researchers with confidence in their results. The Human MMP8 ELISA Kit (ab219050), supported by 3 citations, is an excellent option for researchers looking to accurately measure MMP8 levels in their samples.
Abcam Product Citation Summary
The use of Abcam antibody ab81286 for MMP8 detection highlights its relevance in studying human placental macrophages during Group B Streptococcus (GBS) infection. This suggests a potential role of MMP8 in the immune response within the placenta.
Abcam Product Citation Table
Domain
The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Function
Can degrade fibrillar type I, II, and III collagens.
Sequence Similarities
Belongs to the peptidase M10A family.
Tissue Specificity
Neutrophils.
Cellular localization
- Cytoplasmic granule
- Secreted
- Extracellular space
- Extracellular matrix
- Stored in intracellular granules.
Alternative names
CLG1, MMP8, Neutrophil collagenase, Matrix metalloproteinase-8, PMNL collagenase, MMP-8, PMNL-CL
Database links
swissprot:P22894 entrezGene:4317 omim:120355
Other research areas
- Immunology & Infectious Disease