Mmp8

Developmental stage

Expressed in late embryogenesis and in the involuting postpartum uterus.

Domain

The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.

Function

Can degrade fibrillar type I, II, and III collagens. May play a role in the degradation of collagen fibers during uterine involution.

Sequence Similarities

Belongs to the peptidase M10A family.

Tissue Specificity

Neutrophils. Expressed in uterus. Low levels in kidney and muscle.

Cellular localization

• Cytoplasmic granule
• Secreted
• Extracellular space
• Extracellular matrix
• Stored in intracellular granules and released during inflammatory conditions.

Alternative names

Neutrophil collagenase, Collagenase 2, Matrix metalloproteinase-8, MMP-8, Mmp8

Database links

swissprot:O70138 entrezGene:17394

Other research areas

• Immunology & Infectious Disease