MMRN2
Function
Extracellular matrix protein that plays significant roles in the vascular system and is required for the maintenance and stability of blood vessel (PubMed:28435016). Affects several essential steps in angiogenesis including endothelial cell proliferation, migration, and tube formation. Positively regulates angiogenesis by acting as a ligand for CD93 receptor (PubMed:28671670, PubMed:28912033).
Post-translational modifications
N- and O-glycosylated.
Processed by matrix metalloproteinases (MMPs) including MMP9 and, to a lesser degree, by MMP2 upon angiogenic stimulation.
Tissue Specificity
Endothelium.
Cellular localization
- Secreted
- Extracellular space
- Extracellular matrix
Alternative names
EMILIN3, MMRN2, Multimerin-2, EMILIN-3, Elastin microfibril interface located protein 3, EndoGlyx-1 p125/p140 subunit, Elastin microfibril interfacer 3