MOG
GeneName
MOG
Summary
MOG, also known as myelin oligodendrocyte glycoprotein or MogA, is a 28 kDa glycoprotein predominantly expressed on the external side of the plasma membrane of oligodendrocytes and myelin sheaths in the central nervous system. It plays a critical role in cell adhesion and is involved in the development of the central nervous system. MOG functions as a signaling receptor and has been identified as a receptor for certain viruses, indicating its involvement in immune responses and pathogen interactions. Additionally, it participates in the regulation of cytokine production and T cell receptor signalling pathways, highlighting its importance in immune modulation.
Importance
MOG is relevant to: - Multiple sclerosis and other demyelinating diseases due to its role in myelin integrity and immune response - The study of T cell interactions and autoimmune mechanisms in the central nervous system - Viral infections that target the nervous system, providing insights into pathogen-host interactions - Developmental biology and neuroinflammation, contributing to understanding of central nervous system disorders
Top Products
For researchers investigating MOG, we highly recommend the Anti-Myelin oligodendrocyte glycoprotein antibody [EP4281] (ab109746). This top-selling recombinant antibody has garnered 22 citations, reflecting its strong reputation in the field. It is validated for use in both Western blotting (WB) and immunohistochemistry (IHC), making it an excellent choice for a variety of experimental needs. The reliability and consistency of this antibody will support your research into the role of MOG in oligodendrocyte biology. The Human Myelin oligodendrocyte glycoprotein ELISA Kit (MOG) (ab278115) is an excellent option for researchers looking to measure MOG levels in their samples.
Abcam Product Citation Summary
The data indicates that the MOG antibody (ab109746) is utilised in research focused on myelination, specifically in the prefrontal cortex of mice. This suggests a role for MOG in neurological studies related to myelin formation and maintenance.
Abcam Product Citation Table
Function
Mediates homophilic cell-cell adhesion (By similarity). Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication.
(Microbial infection) Acts as a receptor for rubella virus.
Involvement in disease
Narcolepsy 7
NRCLP7
Neurological disabling sleep disorder, characterized by excessive daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye-movement (REM) sleep, cataplexy, hypnagogic hallucinations, and sleep paralysis. Cataplexy is a sudden loss of muscle tone triggered by emotions, which is the most valuable clinical feature used to diagnose narcolepsy. Human narcolepsy is primarily a sporadically occurring disorder but familial clustering has been observed.
None
The disease is caused by variants affecting the gene represented in this entry.
Sequence Similarities
Belongs to the immunoglobulin superfamily. BTN/MOG family.
Tissue Specificity
Found exclusively in the CNS, where it is localized on the surface of myelin and oligodendrocyte cytoplasmic membranes.
Cellular localization
- Isoform 1
- Cell membrane
- Multi-pass membrane protein
- Isoform 5
- Cell membrane
- Multi-pass membrane protein
- Isoform 2
- Cell membrane
- Single-pass type I membrane protein
- Isoform 3
- Cell membrane
- Single-pass type I membrane protein
- Isoform 4
- Cell membrane
- Single-pass type I membrane protein
- Isoform 6
- Cell membrane
- Single-pass type I membrane protein
- Isoform 7
- Cell membrane
- Single-pass type I membrane protein
- Isoform 8
- Cell membrane
- Single-pass type I membrane protein
- Isoform 9
- Cell membrane
- Single-pass type I membrane protein
Alternative names
Myelin-oligodendrocyte glycoprotein, MOG