Myelin oligodendrocyte glycoprotein

Function

Mediates homophilic cell-cell adhesion (By similarity). Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication.

(Microbial infection) Acts as a receptor for rubella virus.

Involvement in disease

Narcolepsy 7

NRCLP7

Neurological disabling sleep disorder, characterized by excessive daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye-movement (REM) sleep, cataplexy, hypnagogic hallucinations, and sleep paralysis. Cataplexy is a sudden loss of muscle tone triggered by emotions, which is the most valuable clinical feature used to diagnose narcolepsy. Human narcolepsy is primarily a sporadically occurring disorder but familial clustering has been observed.

None

The disease is caused by variants affecting the gene represented in this entry.

Sequence similarities

Belongs to the immunoglobulin superfamily. BTN/MOG family.

Tissue specificity

Found exclusively in the CNS, where it is localized on the surface of myelin and oligodendrocyte cytoplasmic membranes.

Cellular localization

• Isoform 1
• Cell membrane
• Multi-pass membrane protein
• Isoform 5
• Cell membrane
• Multi-pass membrane protein
• Isoform 2
• Cell membrane
• Single-pass type I membrane protein
• Isoform 3
• Cell membrane
• Single-pass type I membrane protein
• Isoform 4
• Cell membrane
• Single-pass type I membrane protein
• Isoform 6
• Cell membrane
• Single-pass type I membrane protein
• Isoform 7
• Cell membrane
• Single-pass type I membrane protein
• Isoform 8
• Cell membrane
• Single-pass type I membrane protein
• Isoform 9
• Cell membrane
• Single-pass type I membrane protein

Alternative names

• Myelin-oligodendrocyte glycoprotein
• MOG

Database links

• entrezGene:4340
• omim:159465
• swissprot:Q16653

Target type

Proteins

Primary research area

Neuroscience

Molecular weight

28193Da