MOK
Function
Able to phosphorylate several exogenous substrates and to undergo autophosphorylation. Negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner.
Post-translational modifications
Autophosphorylated.
Sequence Similarities
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Tissue Specificity
Expressed in heart, brain, lung, kidney, and pancreas, and at very low levels in placenta, liver and skeletal muscle. Detected in retina.
Cellular localization
- Cytoplasm
- Cell projection
- Cilium
- Nucleus
Alternative names
RAGE, RAGE1, MOK, MAPK/MAK/MRK overlapping kinase, MOK protein kinase, Renal tumor antigen 1, RAGE-1