MORC4
Domain
The CW-TYPE zinc finger mediates its binding to trimethylated histone H3K4me3.
Function
Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3 (PubMed:26933034). The order of binding preference is H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0 (PubMed:26933034).
Tissue Specificity
Expressed at low levels in normal tissues, with highest expression levels in placenta and testis. Expression is significantly increased in subset of diffuse large B-cell lymphomas.
Cellular localization
- Nucleus
Alternative names
ZCW4, ZCWCC2, MORC4, MORC family CW-type zinc finger protein 4, Zinc finger CW-type coiled-coil domain protein 2, Zinc finger CW-type domain protein 4