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MPO

Function

Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.

Involvement in disease

Myeloperoxidase deficiency

MPOD

A disorder characterized by decreased myeloperoxidase activity in neutrophils and monocytes that results in disseminated candidiasis.

None

The disease is caused by variants affecting the gene represented in this entry.

Sequence similarities

Belongs to the peroxidase family. XPO subfamily.

Cellular localization

  • Lysosome

Alternative names

  • Myeloperoxidase
  • MPO
  • MPO

Target type

Proteins

Primary research area

Immunology & Infectious Disease

Other research areas

  • Immuno-oncology

Molecular weight

83869Da