MPP2/DLG2

Postsynaptic MAGUK scaffold protein that links CADM1 cell adhesion molecules to core components of the postsynaptic density (By similarity). In CA1 pyramidal neurons, required for synaptic KCNN2-containing channel function and long-term potentiation expression (By similarity). Seems to negatively regulate SRC function in epithelial cells (PubMed:19665017).

Phosphorylated by SRC.

Belongs to the MAGUK family.

• Cytoplasm
• Cytoskeleton
• Membrane
• Cell projection
• Dendrite
• Postsynaptic density
• Prominently expressed in the postsynaptic densities of dendritic spines, is also detected in dendritic shafts.

DLG2, MPP2, MAGUK p55 subfamily member 2, Discs large homolog 2, Protein MPP2

• entrezGene:4355
• omim:600723
• swissprot:Q14168

Proteins

Neuroscience

64581Da