MPP2
Function
Postsynaptic MAGUK scaffold protein that links CADM1 cell adhesion molecules to core components of the postsynaptic density (By similarity). In CA1 pyramidal neurons, required for synaptic KCNN2-containing channel function and long-term potentiation expression (By similarity). Seems to negatively regulate SRC function in epithelial cells (PubMed:19665017).
Post-translational modifications
Phosphorylated by SRC.
Sequence Similarities
Belongs to the MAGUK family.
Cellular localization
- Cytoplasm
- Cytoskeleton
- Membrane
- Cell projection
- Dendrite
- Postsynaptic density
- Prominently expressed in the postsynaptic densities of dendritic spines, is also detected in dendritic shafts.
Alternative names
DLG2, MPP2, MAGUK p55 subfamily member 2, Discs large homolog 2, Protein MPP2