Mpp2
Function
Postsynaptic MAGUK scaffold protein that links CADM1 cell adhesion molecules to core components of the postsynaptic density (By similarity). In CA1 pyramidal neurons, required for synaptic KCNN2-containing channel function and long-term potentiation expression (PubMed:26880549). Seems to negatively regulate SRC function in epithelial cells (By similarity).
Post-translational modifications
Phosphorylated by SRC.
Sequence Similarities
Belongs to the MAGUK family.
Tissue Specificity
Expressed in pyramidal neurons of CA1 region of the hippocampus.
Cellular localization
- Cell projection
- Dendrite
- Postsynaptic density
- Cytoplasm
- Cytoskeleton
- Membrane
- Prominently expressed in the postsynaptic densities of dendritic spines, is also detected in dendritic shafts.
Alternative names
Dlgh2, Mpp2, MAGUK p55 subfamily member 2, Discs large homolog 2, Protein MPP2