Mpz
Function
Is an adhesion molecule necessary for normal myelination in the peripheral nervous system. It mediates adhesion between adjacent myelin wraps and ultimately drives myelin compaction.
Post-translational modifications
N-glycosylated; contains sulfate-substituted glycan.
Sequence Similarities
Belongs to the myelin P0 protein family.
Tissue Specificity
Found only in peripheral nervous system Schwann cells.
Cellular localization
- Cell membrane
- Single-pass type I membrane protein
Alternative names
P0, Myelin protein P0, Myelin peripheral protein, Myelin protein zero, MPP