MRAP2

Modulator of melanocortin receptor 4 (MC4R), a receptor involved in energy homeostasis. Plays a central role in the control of energy homeostasis and body weight regulation by increasing ligand-sensitivity of MC4R and MC4R-mediated generation of cAMP (By similarity). May also act as a negative regulator of MC2R: competes with MRAP for binding to MC2R and impairs the binding of corticotropin (ACTH) to MC2R. May also regulate activity of other melanocortin receptors (MC1R, MC3R and MC5R); however, additional evidence is required in vivo.

Obesity

OBESITY

A condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.

None

Disease susceptibility may be associated with variants affecting the gene represented in this entry.

Belongs to the MRAP family.

Expressed in the adrenal gland and brain. Not expressed in other tissues.

• Cell membrane
• Single-pass membrane protein
• Endoplasmic reticulum membrane
• Single-pass membrane protein
• The formation of antiparallel homo- and heterodimers suggest that N- and C-terminus can both localize in the cytoplasmic and extracellular parts, depending on the context.

C6orf117, MRAP2, Melanocortin-2 receptor accessory protein 2, MC2R accessory protein 2

• entrezGene:112609
• omim:615410
• swissprot:Q96G30

Proteins

Neuroscience

23548Da