MRC1
GeneName
MRC1
Summary
MRC1, also known as the mannose receptor or CD206, is a 166 kDa transmembrane protein predominantly expressed on the surface of macrophages and dendritic cells. It is localised to the cell surface, endosomes, and plasma membrane, where it functions as a cargo receptor that binds D-mannose and other sugars. MRC1 plays a vital role in receptor-mediated endocytosis, facilitating the uptake of glycoproteins and pathogens, including viruses. Additionally, it is involved in the cellular response to various cytokines such as interleukin-4 and type II interferon, linking innate immunity with adaptive immune responses.
Importance
MRC1 is relevant to: - Immune regulation and homeostasis through its role in antigen presentation and modulation of macrophage activity - Pathogen recognition and clearance, particularly in the context of fungal and viral infections - The development of therapeutic strategies targeting MRC1 for enhancing vaccine efficacy or treating inflammatory diseases - Understanding the mechanisms of endocytosis and intracellular trafficking in immune cells
Top Products
For researchers investigating MRC1, we recommend two excellent primary antibodies. The first is the highly regarded polyclonal antibody, Anti-Mannose Receptor antibody (ab64693), which has garnered 1069 citations, underscoring its reliability in immunohistochemistry (IHC). This antibody is a trusted choice for those looking to study MRC1 in tissue samples. Additionally, we offer the recombinant antibody, Anti-Mannose Receptor antibody [EPR6828(B)] (ab125028), which is validated for use in Western blotting (WB). With 65 citations, this product provides a consistent and reliable option for researchers needing precise detection of MRC1. Together, these antibodies offer a comprehensive toolkit for studying this important gene. The Anti-Mannose Receptor antibody ELISA Kit (ab64693), with an impressive 1069 citations, is an excellent option for researchers looking to accurately measure MRC1 in their experiments.
Abcam Product Citation Summary
The data indicates a strong focus on the role of MRC1 in macrophage biology, with multiple studies employing various applications such as Western blotting, immunohistochemistry, and immunofluorescence across different species including humans, rats, and mice. The studies explore contexts such as macrophage activation, polarization, and differentiation, as well as implications in diseases like glioblastoma and renal aging.
Abcam Product Citation Table
Domain
The C-type lectin domains, also called carbohydrate-recognition domains or CRDs, 1-3 have at most very weak affinity for carbohydrates. C-type lectin domain 4 shows the highest affinity binding and has multispecificity for a variety of monosaccharides. At least 3 C-type lectin domains (4, 5, and 7) are required for high affinity binding and endocytosis of multivalent glycoconjugates.
Function
Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains.
(Microbial infection) Acts as a phagocytic receptor for bacteria, fungi and other pathogens.
(Microbial infection) Acts as a receptor for Dengue virus envelope protein E.
(Microbial infection) Interacts with Hepatitis B virus envelope protein.
Cellular localization
- Endosome membrane
- Single-pass type I membrane protein
- Cell membrane
- Single-pass type I membrane protein
Alternative names
CD206, CLEC13D, CLEC13DL, MRC1L1, MRC1, Macrophage mannose receptor 1, MMR, C-type lectin domain family 13 member D, C-type lectin domain family 13 member D-like, Human mannose receptor, Macrophage mannose receptor 1-like protein 1, hMR
Database links
swissprot:P22897 omim:153618 entrezGene:4360
Other research areas
- Immuno-oncology