MRGPRD
Function
May regulate nociceptor function and/or development, including the sensation or modulation of pain. Functions as a specific membrane receptor for beta-alanine. Beta-alanine at micromolar doses specifically evoked Ca(2+) influx in cells expressing the receptor. Beta-alanine decreases forskolin-stimulated cAMP production in cells expressing the receptor, suggesting that the receptor couples with G-protein G(q) and G(i).
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
- Localized at the plasma membrane but internalized into the cytoplasm after treatment with beta-alanine.
Alternative names
MRGD, MRGPRD, Mas-related G-protein coupled receptor member D, Beta-alanine receptor, G-protein coupled receptor TGR7