MRGPRX1
Function
Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22) (PubMed:26582731). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G(alpha)q proteins are involved in the calcium-signaling pathway. Activated by the antimalarial drug, chloroquine. May mediate chloroquine-induced itch, in a histamine-independent manner.
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
Tissue Specificity
Uniquely localized in a subset of small dorsal root and trigeminal sensory neurons.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
Alternative names
MRGX1, SNSR3, SNSR4, MRGPRX1, Mas-related G-protein coupled receptor member X1, Sensory neuron-specific G-protein coupled receptor 3/4