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MRGPRX3

Function

Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins (By similarity).

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. Mas subfamily.

Tissue specificity

Uniquely localized in a subset of small dorsal root and trigeminal sensory neurons.

Cellular localization

  • Cell membrane
  • Multi-pass membrane protein

Alternative names

  • Mas-related G-protein coupled receptor member X3
  • Sensory neuron-specific G-protein coupled receptor 1/2
  • MRGX3
  • SNSR1
  • MRGPRX3
  • SNSR2

Target type

Proteins

Molecular weight

36483Da