MRGPRX4
Function
Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins (By similarity).
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
Tissue Specificity
Uniquely localized in a subset of small dorsal root and trigeminal sensory neurons.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
Alternative names
MRGX4, SNSR5, SNSR6, MRGPRX4, Mas-related G-protein coupled receptor member X4, Sensory neuron-specific G-protein coupled receptor 5/6