MRI1
Function
Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Independently from catalytic activity, promotes cell invasion in response to constitutive RhoA activation by promoting FAK tyrosine phosphorylation and stress fiber turnover.
Pathway
Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6.
Sequence Similarities
Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
Cellular localization
- Nucleus
- Cytoplasm
- Cell projection
- Primarily nuclear, but cytoplasmic in cancer cells, with enrichment at leading edge of the plasma membrane in late stage tumor cells.
Alternative names
MRDI, UNQ6390/PRO21135, MRI1, Methylthioribose-1-phosphate isomerase, M1Pi, MTR-1-P isomerase, Mediator of RhoA-dependent invasion, S-methyl-5-thioribose-1-phosphate isomerase, Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein