The N-terminal region is required for nuclear localization and the C-terminal region mediates transcriptional activity.
Acts as a transcriptional coactivator of serum response factor (SRF). Required for skeletal myogenic differentiation.
A chromosomal aberration involving ZFTA is found in 3 chondroid lipomas. Translocation t(11;16)(q13;p13) with ZFTA produces a ZFTA-MRTFB fusion protein (PubMed:20607705).
O-glycosylated.
KIAA1243, MKL2, MRTFB, Myocardin-related transcription factor B, MRTF-B, MKL/myocardin-like protein 2, Megakaryoblastic leukemia 2
Proteins
Oncology
118127Da
We found 2 products in 1 category
ab242312
ab191496