Ms4a1

Function

B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes. Functions as a store-operated calcium (SOC) channel component promoting calcium influx after activation by the B-cell receptor/BCR.

Post-translational modifications

Phosphorylated.

Sequence Similarities

Belongs to the MS4A family.

Cellular localization

• Cell membrane
• Multi-pass membrane protein
• Cell membrane
• Lipid-anchor
• Constitutively associated with membrane rafts.

Alternative names

CD20, Cd20, Ly-44, Ms4a2, Ms4a1, B-lymphocyte antigen CD20, B-cell differentiation antigen Ly-44, Lymphocyte antigen 44, Membrane-spanning 4-domains subfamily A member 1

Database links

swissprot:P19437 entrezGene:12482

Other research areas

• Immuno-oncology
• Neuroscience