MS4A1
Function
B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes. Functions as a store-operated calcium (SOC) channel component promoting calcium influx after activation by the B-cell receptor/BCR.
Post-translational modifications
Phosphorylated. Might be functionally regulated by protein kinase(s) (By similarity).
Sequence Similarities
Belongs to the MS4A family.
Tissue Specificity
Expressed in PBMCs and lymph node from healthy dogs, in B-cells of canine lymphoma, but not in T-cell lymphoma cells and non-T and non-B-cell lymphoma cells.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
- Cell membrane
- Lipid-anchor
- Constitutively associated with membrane rafts.
Alternative names
CD20, MS4A1, B-lymphocyte antigen CD20, Membrane-spanning 4-domains subfamily A member 1