MS4A3
Domain
The C-terminal region is required for binding to CDKN3-CDK2 complexes and the modulation of CDKN3 activity.
Function
Hematopoietic modulator for the G1-S cell cycle transition. Modulates the level of phosphorylation of cyclin-dependent kinase 2 (CDK2) through its direct binding to cyclin-dependent kinase inhibitor 3 (CDKN3/KAP).
Sequence Similarities
Belongs to the MS4A family.
Tissue Specificity
Expressed specifically in hematopoietic cells and tissues.
Cellular localization
- Endomembrane system
- Multi-pass membrane protein
- Cytoplasm
- Perinuclear region
- Located in the perinuclear area.
Alternative names
CD20L, HTM4, MS4A3, Membrane-spanning 4-domains subfamily A member 3, CD20 antigen-like protein, Hematopoietic-specific transmembrane protein 4, HTm4