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MSI1
Domain
The first RNA recognition motif binds more strongly to RNA compared to the second one.
Function
RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5'-GUUAGUUAGUUAGUU-3' and other sequences containing the pattern 5'-[GA]U(1-3)AGU-3'. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity).
Sequence similarities
Belongs to the Musashi family.
Tissue specificity
Detected in fetal kidney, brain, liver and lung, and in adult brain and pancreas. Detected in hepatoma cell lines.
Cellular localization
- Cytoplasm
- Nucleus
Alternative names
- RNA-binding protein Musashi homolog 1
- Musashi-1
- MSI1
Database links
Target type
Proteins
Primary research area
Oncology
Molecular weight
39125Da