MSLN
Function
Membrane-anchored forms may play a role in cellular adhesion.
Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro.
Involvement in disease
Antibodies against MSLN are detected in patients with mesothelioma and ovarian cancer.
Post-translational modifications
Both MPF and the cleaved form of mesothelin are N-glycosylated.
Proteolytically cleaved by a furin-like convertase to generate megakaryocyte-potentiating factor (MPF), and the cleaved form of mesothelin.
Sequence Similarities
Belongs to the mesothelin family.
Tissue Specificity
Expressed in lung. Expressed at low levels in heart, placenta and kidney. Expressed in mesothelial cells. Highly expressed in mesotheliomas, ovarian cancers, and some squamous cell carcinomas (at protein level).
Cellular localization
- Cell membrane
- Lipid-anchor
- GPI-anchor
- Golgi apparatus
- Megakaryocyte-potentiating factor
- Secreted
- Isoform 3
- Secreted
Alternative names
MPF, MSLN, Mesothelin, CAK1 antigen, Pre-pro-megakaryocyte-potentiating factor