Msln
Developmental stage
Expressed at 7 dpc, down-regulated at 11 dpc, re-expressed at 15 dpc and peaks at 17 dpc. Present in embryonic diaphragm (at protein level).
Function
Membrane-anchored forms may play a role in cellular adhesion.
Megakaryocyte-potentiating factor (MPF) may potentiate megakaryocyte colony formation.
Post-translational modifications
Proteolytically cleaved by a furin-like convertase to generate megakaryocyte-potentiating factor (MPF), and the cleaved form of mesothelin.
Sequence Similarities
Belongs to the mesothelin family.
Tissue Specificity
Highly expressed in lung and heart. Expressed at low levels in spleen, liver, kidney and testis. Present in lung (at protein level).
Cellular localization
- Cell membrane
- Lipid-anchor
- GPI-anchor
- Golgi apparatus
- Megakaryocyte-potentiating factor
- Secreted
Alternative names
Mes, Mpf, Msln, Mesothelin, Pre-pro-megakaryocyte-potentiating factor