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Developmental stage

Expressed at 7 dpc, down-regulated at 11 dpc, re-expressed at 15 dpc and peaks at 17 dpc. Present in embryonic diaphragm (at protein level).

Function

Membrane-anchored forms may play a role in cellular adhesion.

Megakaryocyte-potentiating factor (MPF) may potentiate megakaryocyte colony formation.

Post-translational modifications

Proteolytically cleaved by a furin-like convertase to generate megakaryocyte-potentiating factor (MPF), and the cleaved form of mesothelin.

Sequence similarities

Belongs to the mesothelin family.

Tissue specificity

Highly expressed in lung and heart. Expressed at low levels in spleen, liver, kidney and testis. Present in lung (at protein level).

Cellular localization

  • Cell membrane
  • Lipid-anchor
  • GPI-anchor
  • Golgi apparatus
  • Megakaryocyte-potentiating factor
  • Secreted

Alternative names

Mes, Mpf, Msln, Mesothelin, Pre-pro-megakaryocyte-potentiating factor

Target type

Proteins

Primary research area

Immuno-oncology

Molecular weight

69423Da

We found 7 products in 2 categories

Primary Antibodies

Assay Kits

Reactive species

Detection method